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Microbial
Core Advantages
1. Engineered Host Library: A diverse portfolio of chassis strains with distinct metabolic and post-translational capabilities, tailored to the requirements of different target molecules.

2. Versatile Vector Systems: A broad range of expression vectors designed for multiple applications, enabling flexible solutions to challenges such as low yield and product instability.

3. Optimized Process Strategies: Systematic, multi-parameter optimization to balance cell growth and product expression, ensuring robust productivity and consistent quality.
Clearly sourced, commercially viable strains

No. 

Strain Type

Name

Source

Licensing Fee

1 E.coli

Stbl3 Competent Cells

Thermo Fisther R&D to IND:free
2

DH5α Competent Cells

Thermo Fisther
3

BL21 (DE3) Competent Cells 

Merck
4

Rosetta (DE3) Competent Cells

Merck
5 Yeast

X-33  Pichia pastoris

Thermo Fisther After BLA:TBD
6

GS115  Pichia pastoris

Thermo Fisther
Prokaryotic Engineered Strain Expression Platform

Key Advantages

Multiple plasmid element designs to optimize product expression in engineered strains  

A diverse engineered strain library to meet the needs of different products  

A rapid and efficient screening platform  

Low project cost  

Screening for the optimal production cell line and the most cost-effective induction mode  

High-yield expression of target products  

Flexible operability  

Microbial Expression System Service Scope
Strain Development and Banking
8-Parallel Bioreactor

Engineered Strain Construction  

GMP Banking (MSL/WSL)  

Passage Stability Studies  

GMP-Grade Storage and Cold Chain Transportation

Process Development and Optimization Services
AKTA prue

Medium Screening / Optimization / Formulation Design  

Fermentation Process Development and Optimization  

Purification Process Development and Optimization  

Formulation Process Development and Optimization

GMP Pilot-Scale Production
50/500 L Fermenters

Fermentation Scale-Up and Production  

Purification Scale-Up and Production  

Formulation Production  

Reference Standard Preparation

Analytical Method Development and Quality Control
Capillary Electrophoresis System

Quality Standard Research  

Analytical Method Development and Validation  

Analytical Method Qualification and Transfer  

Stability and Compatibility Studies

Microbial 50L–500L Stainless Steel Production Line
Microbial 50–200L SUB Production Line
The 500L downstream production area is an explosion-proof zone, Class A workshop, equipped with explosion-proof equipment. This area contains low-pressure chromatography columns for capture and intermediate purification of peptide products, as well as DAC high-performance liquid chromatography preparation columns for final polishing. Additionally, the drug substance workshop is equipped with a freeze dryer, allowing the drug substance to be lyophilized into powder for long-term storage.